The main aim of the Mar4Pain project is the development of new pharmaceutical drugs through the investigation and use of new marine compounds for biotechnological purposes. It has particular emphasis on moderate to severe chronic pain, addressing the modulation of ion channel activity in small diameter dorsal root ganglion neurons. This will reduce the perception of pain by acting on pain-conducting neurons away from the brain, which considerably reduces side effects of usual therapies (e.g. opioids). The ion channel modulators consist of new molecules from marine sessile animals from the Portuguese coastal region, which have been discovered through Sea4Us's prior investigation.