{"id":5472,"date":"2020-08-11T22:57:10","date_gmt":"2020-08-11T21:57:10","guid":{"rendered":"https:\/\/sea4us.pt\/?page_id=5472"},"modified":"2026-05-24T13:05:37","modified_gmt":"2026-05-24T12:05:37","slug":"technology","status":"publish","type":"page","link":"https:\/\/sea4us.pt\/en\/technology\/","title":{"rendered":"Technology"},"content":{"rendered":"\t\t
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TECHNOLOGY<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
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Sea4Us combines its core expertise in Marine Biology and Electrophysiology and focuses on compound library generation<\/i><\/b>, drug discovery <\/i><\/b>and preclinical development <\/i><\/b>from marine substances and compounds. We screen such compounds against a number of therapeutic targets<\/b>.<\/p>\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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\"\"<\/figure>

MARINE BIOLOGY<\/h4>

PHOTOGRAPHY\n\nJo\u00e3o Rodrigues | CHIMERAVISUALS<\/p><\/div><\/div>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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Our discovery begins in the ocean: the interaction between species and their compounds\u2019 bioactivities are the initial phase of our process of drug discovery. \u00a0Millions of years of evolution on marine animals resulted in highly specialized and ingenious solutions for defense against predators, comprising compounds that have demonstrated a wide range of pharmacological properties.<\/em><\/p>\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t

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\"\"<\/figure>

ELECTROPHYSIOLOGY<\/h4>

PHOTOGRAPHY\n\nJo\u00e3o Rodrigues | CHIMERAVISUALS<\/p><\/div><\/div>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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The elecrophysiological testing allows to assess neuronal bioactivity for each compound of our compound library as 0ur therapeutic targets are the ion channels involved in pathologies. After such validation, in silico and ex vivo assays are performed to assess toxicity levels.<\/em><\/p>\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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PIPELINE<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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<\/div>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
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development phase<\/p>\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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therapeutic area<\/p>\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t

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discovery<\/p>\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t

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Lead Optimization
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Preclinical Development<\/p>\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t

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CTA<\/p>\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t

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Phase 1 CT<\/p>\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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Neuropathic Pain<\/p>\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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musculoskeletal Pain<\/p>\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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Chemotherapy Pain<\/p>\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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urology<\/p>\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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CNS \/ Epilepsy<\/p>\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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infectious diseases<\/p>\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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METHODOLOGY<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Animal Research at Sea4Us<\/h6>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Sea4Us is a signatory to the Transparency Agreement on Animal Research in Portugal. This is an initiative supported by the scientific community in collaboration with the European Animal Research Association (EARA) to promote transparency and openness about the use of animals in biomedical research in our country.<\/span> <\/span><\/p>\n

Sea4Us records the vital role that the use of animals plays in scientific research in terms of contributing to the knowledge and well-being of humans and animals, and implements the principle of the 3Rs \u2013 Replacement, Reduction and Refinement -, to ensure that it uses the least amount of animals possible, always focusing on animal well-being throughout the experiments. The welfare of animals used in research is a fundamental issue and research carried out in our institution strictly respects Portuguese (Decree-law no. 113\/2017, of August 7) and European (Directive no. 63\/2010\/EU) regulations that govern the use of animals in research.<\/span> <\/span><\/p>\n

The humane use of animals in research carried out at Sea4Us complies with legal standards and is reviewed by the Ethics Committee and the Body responsible for animal welfare that promotes the principle of the 3Rs. No research project that requires the use of animals begins without an assessment of both animal welfare and an ethical assessment and authorization from the competent authority. It is also ensured that both the people responsible for caring for the animals and the researchers involved in animal experimentation have the necessary training and knowledge to carry out animal research.<\/span><\/p>\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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\n\t\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\tResumo N\u00e3o T\u00e9cnico Pain Research\t\t\t\t<\/a>\n\t\t\t\t\t\t<\/div>\n <\/div>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t
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\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"

TECHNOLOGY Sea4Us combines its core expertise in Marine Biology and Electrophysiology and focuses on compound library generation, drug discovery and preclinical development from marine substances and compounds. We screen such compounds against a number of therapeutic targets. MARINE BIOLOGY PHOTOGRAPHY Jo\u00e3o Rodrigues | CHIMERAVISUALS Our discovery begins in the ocean: the interaction between species and […]<\/p>\n","protected":false},"author":2,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"elementor_header_footer","meta":{"footnotes":""},"class_list":["post-5472","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/sea4us.pt\/en\/wp-json\/wp\/v2\/pages\/5472","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/sea4us.pt\/en\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/sea4us.pt\/en\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/sea4us.pt\/en\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/sea4us.pt\/en\/wp-json\/wp\/v2\/comments?post=5472"}],"version-history":[{"count":131,"href":"https:\/\/sea4us.pt\/en\/wp-json\/wp\/v2\/pages\/5472\/revisions"}],"predecessor-version":[{"id":8183,"href":"https:\/\/sea4us.pt\/en\/wp-json\/wp\/v2\/pages\/5472\/revisions\/8183"}],"wp:attachment":[{"href":"https:\/\/sea4us.pt\/en\/wp-json\/wp\/v2\/media?parent=5472"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}