{"id":7782,"date":"2026-05-01T12:10:52","date_gmt":"2026-05-01T11:10:52","guid":{"rendered":"https:\/\/sea4us.pt\/?p=7782"},"modified":"2026-05-05T15:32:50","modified_gmt":"2026-05-05T14:32:50","slug":"clinical-trial-application-approval","status":"publish","type":"post","link":"https:\/\/sea4us.pt\/en\/clinical-trial-application-approval\/","title":{"rendered":"Clinical Trial Application Approved!"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"7782\" class=\"elementor elementor-7782\">\n\t\t\t\t\t\t<div class=\"elementor-inner\">\n\t\t\t\t<div class=\"elementor-section-wrap\">\n\t\t\t\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-d89054d elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"d89054d\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t\t\t<div class=\"elementor-row\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-b2d5e3e\" data-id=\"b2d5e3e\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-column-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t<div class=\"elementor-widget-wrap\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-58c1bcf elementor-widget elementor-widget-spacer\" data-id=\"58c1bcf\" data-element_type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-62ff80d elementor-widget elementor-widget-heading\" data-id=\"62ff80d\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Clinical Trial Application APPROVed <\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-64801aa elementor-arrows-position-inside elementor-pagination-position-outside elementor-widget elementor-widget-image-carousel\" data-id=\"64801aa\" data-element_type=\"widget\" data-settings=\"{&quot;slides_to_show&quot;:&quot;3&quot;,&quot;slides_to_scroll&quot;:&quot;1&quot;,&quot;image_spacing_custom&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:3,&quot;sizes&quot;:[]},&quot;navigation&quot;:&quot;both&quot;,&quot;autoplay&quot;:&quot;yes&quot;,&quot;pause_on_hover&quot;:&quot;yes&quot;,&quot;pause_on_interaction&quot;:&quot;yes&quot;,&quot;autoplay_speed&quot;:5000,&quot;infinite&quot;:&quot;yes&quot;,&quot;speed&quot;:500}\" data-widget_type=\"image-carousel.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-image-carousel-wrapper swiper-container\" dir=\"ltr\">\n\t\t\t<div class=\"elementor-image-carousel swiper-wrapper\">\n\t\t\t\t\t\t\t\t<div class=\"swiper-slide\"><figure class=\"swiper-slide-inner\"><img decoding=\"async\" class=\"swiper-slide-image\" src=\"https:\/\/sea4us.pt\/wp-content\/uploads\/2026\/05\/1-1040x1300.png\" alt=\"CTA1\" \/><\/figure><\/div><div class=\"swiper-slide\"><figure class=\"swiper-slide-inner\"><img decoding=\"async\" class=\"swiper-slide-image\" src=\"https:\/\/sea4us.pt\/wp-content\/uploads\/2026\/05\/2-1040x1300.png\" alt=\"CTA2\" \/><\/figure><\/div><div class=\"swiper-slide\"><figure class=\"swiper-slide-inner\"><img decoding=\"async\" class=\"swiper-slide-image\" src=\"https:\/\/sea4us.pt\/wp-content\/uploads\/2026\/05\/3-1040x1300.png\" alt=\"CTA3\" \/><\/figure><\/div><div class=\"swiper-slide\"><figure class=\"swiper-slide-inner\"><img decoding=\"async\" class=\"swiper-slide-image\" src=\"https:\/\/sea4us.pt\/wp-content\/uploads\/2026\/05\/4-1040x1300.png\" alt=\"CTA4\" \/><\/figure><\/div><div class=\"swiper-slide\"><figure class=\"swiper-slide-inner\"><img decoding=\"async\" class=\"swiper-slide-image\" src=\"https:\/\/sea4us.pt\/wp-content\/uploads\/2026\/05\/5-1040x1300.png\" alt=\"CTA5\" \/><\/figure><\/div>\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"swiper-pagination\"><\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"elementor-swiper-button elementor-swiper-button-prev\">\n\t\t\t\t\t\t<i aria-hidden=\"true\" class=\"eicon-chevron-left\"><\/i>\t\t\t\t\t\t<span class=\"elementor-screen-only\">Previous<\/span>\n\t\t\t\t\t<\/div>\n\t\t\t\t\t<div class=\"elementor-swiper-button elementor-swiper-button-next\">\n\t\t\t\t\t\t<i aria-hidden=\"true\" class=\"eicon-chevron-right\"><\/i>\t\t\t\t\t\t<span class=\"elementor-screen-only\">Next<\/span>\n\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-4f3e572 elementor-section-stretched elementor-section-content-space-evenly elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"4f3e572\" data-element_type=\"section\" data-settings=\"{&quot;stretch_section&quot;:&quot;section-stretched&quot;}\">\n\t\t\t\t\t\t\t<div class=\"elementor-background-overlay\"><\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-narrow\">\n\t\t\t\t\t\t\t<div class=\"elementor-row\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-ad8014c\" data-id=\"ad8014c\" data-element_type=\"column\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t<div class=\"elementor-column-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t<div class=\"elementor-widget-wrap\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-7ad3e63 elementor-widget elementor-widget-heading\" data-id=\"7ad3e63\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Green light on S072 <\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-aaf9ae2 elementor-widget elementor-widget-spacer\" data-id=\"aaf9ae2\" data-element_type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-8c9414b elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"8c9414b\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t\t\t<div class=\"elementor-row\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-995b58d\" data-id=\"995b58d\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-column-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t<div class=\"elementor-widget-wrap\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-49f8374 elementor-widget elementor-widget-text-editor\" data-id=\"49f8374\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-text-editor elementor-clearfix\">\n\t\t\t\t<p><b>Sea4Us\u2019 first-in-class analgesic regulatory and ethical approval back S072\u2019s promising efficacy with preclinical safety.<\/b><\/p><p><b>Clinical site activation took take place on April 30<\/b><b>th<\/b><b> 2026<\/b><b>.<\/b><\/p>\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-61cdaf8 elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"61cdaf8\" data-element_type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-8904939 elementor-widget elementor-widget-text-editor\" data-id=\"8904939\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-text-editor elementor-clearfix\">\n\t\t\t\t<p><b>Sagres<\/b><b>, Portugal, May 1st, 2026<\/b> &#8211; Sea4Us is a biotechnology company developing <i>new marine leads for unmet clinical needs<\/i>, and its lead project is a first in class analgesic for the treatment of chronic and acute pain.<\/p><p>Sea4Us today announces the achievement of a major milestone, with the approval of its clinical trial application (CTA) by regulatory authorities. Sea4Us will soon start First in Humans activities.<\/p><p>Strong preclinical safety and product profile back S072\u2019s promising and superior efficacy when compared to the standards of care (e.g., opioids), are a critical step towards establishment of safety in humans (Phase 1 clinical trials).<\/p><p>Clinical Strategy for S072 starts with post-surgery medical indication, later to be expanded to chronic pain indications.<\/p>\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-6d541bf elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"6d541bf\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t\t\t<div class=\"elementor-row\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-0b70efd\" data-id=\"0b70efd\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-column-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t<div class=\"elementor-widget-wrap\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-0692aed elementor-widget elementor-widget-heading\" data-id=\"0692aed\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">1st in class non-opiod analgesic <\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-66d2400 elementor-widget elementor-widget-text-editor\" data-id=\"66d2400\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-text-editor elementor-clearfix\">\n\t\t\t\t<p>Our drug candidate, S072, is a small-molecule, inspired in a marine molecule and optimized for human health, that targets hyperactive peripheral neurons via selective modulation of key ion channels. This peripheral mechanism allows for potent analgesia without central nervous system side effects, eliminating risks of addiction, sedation, or cognitive impairment.<\/p><p>The drug candidate is intended for up to twice-daily oral dosing and has demonstrated an excellent safety profile during the GLP preclinical tests, with superior efficacy and duration of effect in head-to-head comparisons with the standards of care (e.g., morphine).<\/p><p>Pharmacokinetic studies show high oral bioavailability in preclinical species, elevated plasma exposure, low protein binding, and high hepatic stability in rats, dogs, and humans. Safety pharmacology indicates no significant CYP interactions, off-target effects, or behavioral toxicity. The compound is well tolerated, with a high safety margin. Robust efficacy proof-of-concept data has been generated across six validated animal models of disease, including post-operative pain, osteoarthritic pain, trigeminal neuralgia, chemotherapy-induced peripheral neuropathy, visceral pain\/IBD, and monoarthritic pain.<\/p><p>Three patents have been submitted. Two are granted in the United States, and the third patent entered PCT in 2025 and was published in January 2026.<\/p><p>Clinical Strategy for S072 starts with post-surgery medical indication, later to be expanded to chronic pain indications.<\/p>\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-13f6e8e elementor-section-content-space-evenly elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"13f6e8e\" data-element_type=\"section\">\n\t\t\t\t\t\t\t<div class=\"elementor-background-overlay\"><\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-narrow\">\n\t\t\t\t\t\t\t<div class=\"elementor-row\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-3ef560d\" data-id=\"3ef560d\" data-element_type=\"column\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t<div class=\"elementor-column-wrap elementor-element-populated\">\n\t\t\t\t\t<div class=\"elementor-background-overlay\"><\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-widget-wrap\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-770a053 elementor-widget elementor-widget-heading\" data-id=\"770a053\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Manufacturing Completed for Clinical Trials\n <\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-7c1580c elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"7c1580c\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t\t\t<div class=\"elementor-row\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-850087b\" data-id=\"850087b\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-column-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t<div class=\"elementor-widget-wrap\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-d1ff894 elementor-widget elementor-widget-text-editor\" data-id=\"d1ff894\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-text-editor elementor-clearfix\">\n\t\t\t\t<p>S072 is a <b>novel chemical entity <\/b>(<b>NCE<\/b>) that is simple to synthesize chemically and highly stable.<\/p><p><b>Industrial up-scale <\/b>is established, with both GLP and GMP certified qualifications and with high purity.<\/p>\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-a19694c\" data-id=\"a19694c\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-column-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t<div class=\"elementor-widget-wrap\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-ebc0bd6 elementor-widget elementor-widget-text-editor\" data-id=\"ebc0bd6\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-text-editor elementor-clearfix\">\n\t\t\t\t<p>The <b>Drug Substance <\/b>for Clinical Trials has been manufactured with ongoing ICH-conform stability.<\/p><p><b>Drug Product <\/b>is established as simple formulation. Clinical materials have been produced.<\/p>\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-4015f2f elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"4015f2f\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t\t\t<div class=\"elementor-row\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-5e827f6\" data-id=\"5e827f6\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-column-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t<div class=\"elementor-widget-wrap\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-fbdc644 elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"fbdc644\" data-element_type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-39390bf elementor-section-stretched elementor-section-content-space-evenly elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"39390bf\" data-element_type=\"section\" data-settings=\"{&quot;stretch_section&quot;:&quot;section-stretched&quot;}\">\n\t\t\t\t\t\t\t<div class=\"elementor-background-overlay\"><\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-narrow\">\n\t\t\t\t\t\t\t<div class=\"elementor-row\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-3bec182\" data-id=\"3bec182\" data-element_type=\"column\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t<div class=\"elementor-column-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t<div class=\"elementor-widget-wrap\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-c34ed57 elementor-widget elementor-widget-heading\" data-id=\"c34ed57\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">What is Chronic Pain, how widespread it is, and its implications are for individuals and society <\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-ec3252c elementor-widget elementor-widget-spacer\" data-id=\"ec3252c\" data-element_type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-95a78c5 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"95a78c5\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t\t\t<div class=\"elementor-row\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-575298c\" data-id=\"575298c\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-column-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t<div class=\"elementor-widget-wrap\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-2acff5d elementor-widget elementor-widget-text-editor\" data-id=\"2acff5d\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-text-editor elementor-clearfix\">\n\t\t\t\t<p>If someone has persistent or recurring pain for more than <a href=\"https:\/\/www.iasp-pain.org\/advocacy\/definitions-of-chronic-pain-syndromes\/\">three<\/a> months, they are considered to have chronic pain. Chronic pain is <a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC6676152\/\">regarded<\/a> as a condition, rather than just an accompanying symptom. Various factors, including those of a biological, psychological, and social nature, <a href=\"https:\/\/www.iasp-pain.org\/advocacy\/definitions-of-chronic-pain-syndromes\/\">contribute<\/a> to this type of pain.<\/p><p>An estimated <a href=\"https:\/\/europeanpainfederation.eu\/imi\/the-future-of-european-pain-research-in-the-european-parliament-march-2023\/?utm_source=chatgpt.com\">100 million<\/a> people in Europe and <a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC11609938\/?utm_source=chatgpt.com\">1.6 billion<\/a> worldwide suffer from chronic pain, which has been <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/37053114\/\">linked<\/a> to depression, a higher suicide rate, as well as substance use and misuse. Chronic pain patients have limited quality of life, with a significant toll on an individual&#8217;s family and social relationships, and a higher likelihood of leaving the workforce \u2013 it costs Europe alone about <a href=\"https:\/\/www.activecitizenship.net\/pressreleases\/319?utm_source=chatgpt.com\">\u20ac500 billion<\/a> a year with similar numbers in the US.<\/p><p>There are medications available for the treatment of chronic pain, but many are either ineffective for certain types of pain and severity or, in the case of opioid drugs, have significant side effects, including the risk of addiction and dependence. This leaves patients and doctor with limited treatment options, if any, and always at the cost of safety or proper pain management.<\/p>\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-7bd541a elementor-section-content-space-evenly elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"7bd541a\" data-element_type=\"section\">\n\t\t\t\t\t\t\t<div class=\"elementor-background-overlay\"><\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-narrow\">\n\t\t\t\t\t\t\t<div class=\"elementor-row\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-fa553ef\" data-id=\"fa553ef\" data-element_type=\"column\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t<div class=\"elementor-column-wrap elementor-element-populated\">\n\t\t\t\t\t<div class=\"elementor-background-overlay\"><\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-widget-wrap\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-ec284f2 elementor-widget elementor-widget-heading\" data-id=\"ec284f2\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">More About Sea4Us <\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-6b7617f elementor-widget elementor-widget-text-editor\" data-id=\"6b7617f\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-text-editor elementor-clearfix\">\n\t\t\t\t<p>Sea4Us was launched in 2013 as a spin-off from NOVA University of Lisbon, with the mission to bring novel marine-inspired compounds to address unmet clinical needs, particularly those with ion channels as therapeutic targets.<\/p><p>Sea4Us\u2019 unique approach combines marine biology and electrophysiology to open new avenues for a wide range of acute and chronic conditions. Sea4Us\u2019 research and use are protected, with some patents already granted.<\/p><p>Sea4Us currently employs 20 people, and since its creation has raised 6.8M\u20ac in private equity and grants.<\/p>\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-2f90b90 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"2f90b90\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t\t\t<div class=\"elementor-row\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-088f1e7\" data-id=\"088f1e7\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-column-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t<div class=\"elementor-widget-wrap\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-bc44537 elementor-widget elementor-widget-image\" data-id=\"bc44537\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-image\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t<a href=\"https:\/\/sea4us.pt\/sobre-nos\/projects\/sea4market\/\">\n\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"118\" src=\"https:\/\/sea4us.pt\/wp-content\/uploads\/2024\/06\/EU-1024x118.png\" class=\"attachment-large size-large\" alt=\"\" srcset=\"https:\/\/sea4us.pt\/wp-content\/uploads\/2024\/06\/EU-1024x118.png 1024w, https:\/\/sea4us.pt\/wp-content\/uploads\/2024\/06\/EU-300x35.png 300w, https:\/\/sea4us.pt\/wp-content\/uploads\/2024\/06\/EU-768x88.png 768w, https:\/\/sea4us.pt\/wp-content\/uploads\/2024\/06\/EU-1536x177.png 1536w, https:\/\/sea4us.pt\/wp-content\/uploads\/2024\/06\/EU-1040x120.png 1040w, https:\/\/sea4us.pt\/wp-content\/uploads\/2024\/06\/EU.png 1807w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/>\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-c32c0e3 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"c32c0e3\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t\t\t<div class=\"elementor-row\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-33 elementor-top-column elementor-element elementor-element-a82c565\" data-id=\"a82c565\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-column-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t<div class=\"elementor-widget-wrap\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-ef85140 elementor-widget elementor-widget-elementskit-heading\" data-id=\"ef85140\" data-element_type=\"widget\" data-widget_type=\"elementskit-heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<div class=\"ekit-wid-con\" ><div class=\"ekit-heading elementskit-section-title-wraper text_left   ekit_heading_tablet-   ekit_heading_mobile-\"><h2 class=\"ekit-heading--title elementskit-section-title \">\n\t\t\t\t\tBack to News\n\t\t\t\t<\/h2><div class=\"ekit_heading_separetor_wraper ekit_heading_elementskit-border-divider elementskit-style-long\"><div class=\"elementskit-border-divider elementskit-style-long\"><\/div><\/div><\/div><\/div>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-417b2c0 elementor-align-left elementor-widget elementor-widget-button\" data-id=\"417b2c0\" data-element_type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t<a href=\"https:\/\/sea4us.pt\/en\/news-2\/\" class=\"elementor-button-link elementor-button elementor-size-lg elementor-animation-grow\" role=\"button\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t<span class=\"elementor-button-text\">NEWS<\/span>\n\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-66 elementor-top-column elementor-element elementor-element-c04b991\" data-id=\"c04b991\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-column-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t<div class=\"elementor-widget-wrap\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-6bfffc2 elementor-grid-3 elementor-grid-tablet-2 elementor-grid-mobile-1 elementor-widget elementor-widget-elementor-blog-posts\" data-id=\"6bfffc2\" data-element_type=\"widget\" data-settings=\"{&quot;columns&quot;:&quot;3&quot;,&quot;columns_tablet&quot;:&quot;2&quot;,&quot;columns_mobile&quot;:&quot;1&quot;}\" data-widget_type=\"elementor-blog-posts.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"wpcap-grid\">\n\t\t\t\t\t\t<div class=\"wpcap-grid-container elementor-grid wpcap-grid-desktop-3 wpcap-grid-tablet-2 wpcap-grid-mobile-1 grid-meta-bottom\">\n\n\t\t\t\t\n        <article id=\"post-8271\" class=\"wpcap-post post-8271 post type-post status-publish format-standard hentry category-news\">\n         \n            <div class=\"post-grid-inner\">\n            \t\n            \t\n                <div class=\"post-grid-text-wrap\">\n               \t\t\t\t<h2 class=\"title\">\n\t\t\t<a href=\"https:\/\/sea4us.pt\/en\/sea4us-featured-at-rtps-sociedade-civil\/\">Sea4Us featured at RTP&#8217;s Sociedade Civil<\/a>\n\t\t<\/h2>\n\t\t\t                \t                                <\/div>\n\n                \t\t<div class=\"post-grid-meta\">\n\t\t\t\n\t\t\t\t<span class=\"post-date\"><time datetime=\"2026-06-22T16:55:09+00:00\">22\/06\/2026<\/time><\/span>\n\n\t\t\t\t\t\t<\/div>\n\t\t\n            <\/div><!-- .blog-inner -->\n           \n        <\/article>\n\n        \n        <article id=\"post-8122\" class=\"wpcap-post post-8122 post type-post status-publish format-standard hentry category-news\">\n         \n            <div class=\"post-grid-inner\">\n            \t\n            \t\n                <div class=\"post-grid-text-wrap\">\n               \t\t\t\t<h2 class=\"title\">\n\t\t\t<a href=\"https:\/\/sea4us.pt\/en\/sea4us-featured-in-sabado-portuguese-discoveries-with-the-potential-to-transform-pain-treatment\/\">Sea4Us featured in S\u00c1BADO: Portuguese discoveries with the potential to transform pain treatment<\/a>\n\t\t<\/h2>\n\t\t\t                \t                                <\/div>\n\n                \t\t<div class=\"post-grid-meta\">\n\t\t\t\n\t\t\t\t<span class=\"post-date\"><time datetime=\"2026-05-18T16:22:14+00:00\">18\/05\/2026<\/time><\/span>\n\n\t\t\t\t\t\t<\/div>\n\t\t\n            <\/div><!-- .blog-inner -->\n           \n        <\/article>\n\n        \n        <article id=\"post-7782\" class=\"wpcap-post post-7782 post type-post status-publish format-standard hentry category-long-post category-news\">\n         \n            <div class=\"post-grid-inner\">\n            \t\n            \t\n                <div class=\"post-grid-text-wrap\">\n               \t\t\t\t<h2 class=\"title\">\n\t\t\t<a href=\"https:\/\/sea4us.pt\/en\/clinical-trial-application-approval\/\">Clinical Trial Application Approved!<\/a>\n\t\t<\/h2>\n\t\t\t                \t                                <\/div>\n\n                \t\t<div class=\"post-grid-meta\">\n\t\t\t\n\t\t\t\t<span class=\"post-date\"><time datetime=\"2026-05-01T12:10:52+00:00\">01\/05\/2026<\/time><\/span>\n\n\t\t\t\t\t\t<\/div>\n\t\t\n            <\/div><!-- .blog-inner -->\n           \n        <\/article>\n\n        \n\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Clinical Trial Application APPROVed Previous Next Green light on S072 Sea4Us\u2019 first-in-class analgesic regulatory and ethical approval back S072\u2019s promising efficacy with preclinical safety. Clinical site activation took take place on April 30th 2026. Sagres, Portugal, May 1st, 2026 &#8211; Sea4Us is a biotechnology company developing new marine leads for unmet clinical needs, and its [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"elementor_header_footer","format":"standard","meta":{"footnotes":""},"categories":[10,38],"tags":[],"class_list":["post-7782","post","type-post","status-publish","format-standard","hentry","category-long-post","category-news"],"_links":{"self":[{"href":"https:\/\/sea4us.pt\/en\/wp-json\/wp\/v2\/posts\/7782","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/sea4us.pt\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/sea4us.pt\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/sea4us.pt\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/sea4us.pt\/en\/wp-json\/wp\/v2\/comments?post=7782"}],"version-history":[{"count":84,"href":"https:\/\/sea4us.pt\/en\/wp-json\/wp\/v2\/posts\/7782\/revisions"}],"predecessor-version":[{"id":8041,"href":"https:\/\/sea4us.pt\/en\/wp-json\/wp\/v2\/posts\/7782\/revisions\/8041"}],"wp:attachment":[{"href":"https:\/\/sea4us.pt\/en\/wp-json\/wp\/v2\/media?parent=7782"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/sea4us.pt\/en\/wp-json\/wp\/v2\/categories?post=7782"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/sea4us.pt\/en\/wp-json\/wp\/v2\/tags?post=7782"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}