{"id":7782,"date":"2026-05-01T12:10:52","date_gmt":"2026-05-01T11:10:52","guid":{"rendered":"https:\/\/sea4us.pt\/?p=7782"},"modified":"2026-05-05T15:32:50","modified_gmt":"2026-05-05T14:32:50","slug":"clinical-trial-application-approval","status":"publish","type":"post","link":"https:\/\/sea4us.pt\/pt\/clinical-trial-application-approval\/","title":{"rendered":"Submiss\u00e3o a Ensaios Cl\u00ednicos Aprovada!"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"7782\" class=\"elementor elementor-7782\">\n\t\t\t\t\t\t<div class=\"elementor-inner\">\n\t\t\t\t<div class=\"elementor-section-wrap\">\n\t\t\t\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-d89054d elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"d89054d\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t\t\t<div class=\"elementor-row\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-b2d5e3e\" data-id=\"b2d5e3e\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-column-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t<div class=\"elementor-widget-wrap\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-58c1bcf elementor-widget elementor-widget-spacer\" data-id=\"58c1bcf\" data-element_type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-62ff80d elementor-widget elementor-widget-heading\" data-id=\"62ff80d\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Pedido de Autoriza\u00e7\u00e3o de Ensaio Cl\u00ednico APROVADO<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-64801aa elementor-arrows-position-inside elementor-pagination-position-outside elementor-widget elementor-widget-image-carousel\" data-id=\"64801aa\" data-element_type=\"widget\" data-settings=\"{&quot;slides_to_show&quot;:&quot;3&quot;,&quot;slides_to_scroll&quot;:&quot;1&quot;,&quot;image_spacing_custom&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:3,&quot;sizes&quot;:[]},&quot;navigation&quot;:&quot;both&quot;,&quot;autoplay&quot;:&quot;yes&quot;,&quot;pause_on_hover&quot;:&quot;yes&quot;,&quot;pause_on_interaction&quot;:&quot;yes&quot;,&quot;autoplay_speed&quot;:5000,&quot;infinite&quot;:&quot;yes&quot;,&quot;speed&quot;:500}\" data-widget_type=\"image-carousel.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-image-carousel-wrapper swiper-container\" dir=\"ltr\">\n\t\t\t<div class=\"elementor-image-carousel swiper-wrapper\">\n\t\t\t\t\t\t\t\t<div class=\"swiper-slide\"><figure class=\"swiper-slide-inner\"><img decoding=\"async\" class=\"swiper-slide-image\" src=\"https:\/\/sea4us.pt\/wp-content\/uploads\/2026\/05\/1-1040x1300.png\" alt=\"CTA1\" \/><\/figure><\/div><div class=\"swiper-slide\"><figure class=\"swiper-slide-inner\"><img decoding=\"async\" class=\"swiper-slide-image\" src=\"https:\/\/sea4us.pt\/wp-content\/uploads\/2026\/05\/2-1040x1300.png\" alt=\"CTA2\" \/><\/figure><\/div><div class=\"swiper-slide\"><figure class=\"swiper-slide-inner\"><img decoding=\"async\" class=\"swiper-slide-image\" src=\"https:\/\/sea4us.pt\/wp-content\/uploads\/2026\/05\/3-1040x1300.png\" alt=\"CTA3\" \/><\/figure><\/div><div class=\"swiper-slide\"><figure class=\"swiper-slide-inner\"><img decoding=\"async\" class=\"swiper-slide-image\" src=\"https:\/\/sea4us.pt\/wp-content\/uploads\/2026\/05\/4-1040x1300.png\" alt=\"CTA4\" \/><\/figure><\/div><div class=\"swiper-slide\"><figure class=\"swiper-slide-inner\"><img decoding=\"async\" class=\"swiper-slide-image\" src=\"https:\/\/sea4us.pt\/wp-content\/uploads\/2026\/05\/5-1040x1300.png\" alt=\"CTA5\" \/><\/figure><\/div>\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"swiper-pagination\"><\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"elementor-swiper-button elementor-swiper-button-prev\">\n\t\t\t\t\t\t<i aria-hidden=\"true\" class=\"eicon-chevron-left\"><\/i>\t\t\t\t\t\t<span class=\"elementor-screen-only\">Anterior<\/span>\n\t\t\t\t\t<\/div>\n\t\t\t\t\t<div class=\"elementor-swiper-button elementor-swiper-button-next\">\n\t\t\t\t\t\t<i aria-hidden=\"true\" class=\"eicon-chevron-right\"><\/i>\t\t\t\t\t\t<span class=\"elementor-screen-only\">Seguinte<\/span>\n\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-4f3e572 elementor-section-stretched elementor-section-content-space-evenly elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"4f3e572\" data-element_type=\"section\" data-settings=\"{&quot;stretch_section&quot;:&quot;section-stretched&quot;}\">\n\t\t\t\t\t\t\t<div class=\"elementor-background-overlay\"><\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-narrow\">\n\t\t\t\t\t\t\t<div class=\"elementor-row\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-ad8014c\" data-id=\"ad8014c\" data-element_type=\"column\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t<div class=\"elementor-column-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t<div class=\"elementor-widget-wrap\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-7ad3e63 elementor-widget elementor-widget-heading\" data-id=\"7ad3e63\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Luz verde para o S072<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-aaf9ae2 elementor-widget elementor-widget-spacer\" data-id=\"aaf9ae2\" data-element_type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-8c9414b elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"8c9414b\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t\t\t<div class=\"elementor-row\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-995b58d\" data-id=\"995b58d\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-column-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t<div class=\"elementor-widget-wrap\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-49f8374 elementor-widget elementor-widget-text-editor\" data-id=\"49f8374\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-text-editor elementor-clearfix\">\n\t\t\t\t<p><strong>A aprova\u00e7\u00e3o regulamentar e \u00e9tica do analg\u00e9sico <em>first-in-class<\/em> da Sea4Us sustenta a efic\u00e1cia promissora do S072, suportada pela sua seguran\u00e7a pr\u00e9-cl\u00ednica.<\/strong><\/p><p><strong>A ativa\u00e7\u00e3o do centro cl\u00ednico teve lugar a 30 de abril de 2026.<\/strong><\/p>\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-61cdaf8 elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"61cdaf8\" data-element_type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-8904939 elementor-widget elementor-widget-text-editor\" data-id=\"8904939\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-text-editor elementor-clearfix\">\n\t\t\t\t<p><strong>Sagres, Portugal, 1 de maio de 2026<\/strong> &#8211; A Sea4Us \u00e9 uma empresa de biotecnologia que desenvolve<em> novos leads de origem marinha para necessidades cl\u00ednicas n\u00e3o satisfeitas<\/em>, tendo como projeto principal um analg\u00e9sico <em>first-in-class<\/em> para o tratamento da dor cr\u00f3nica e aguda.<\/p><p>A Sea4Us anuncia hoje a concretiza\u00e7\u00e3o de um marco importante, com a aprova\u00e7\u00e3o do seu pedido de autoriza\u00e7\u00e3o para ensaio cl\u00ednico (CTA) pelas autoridades regulamentares. A Sea4Us iniciar\u00e1 brevemente as atividades First-in-Human.<\/p><p>A forte seguran\u00e7a pr\u00e9-cl\u00ednica e o perfil do produto sustentam a efic\u00e1cia promissora e superior do S072 quando comparado com os standards of care (por exemplo, opioides), constituindo um passo cr\u00edtico para o estabelecimento da seguran\u00e7a em humanos (ensaios cl\u00ednicos de Fase 1).<\/p><p>A estrat\u00e9gia cl\u00ednica para o S072 tem in\u00edcio na indica\u00e7\u00e3o m\u00e9dica de dor p\u00f3s-cir\u00fargica, sendo posteriormente expandida para indica\u00e7\u00f5es de dor cr\u00f3nica.<\/p>\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-6d541bf elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"6d541bf\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t\t\t<div class=\"elementor-row\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-0b70efd\" data-id=\"0b70efd\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-column-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t<div class=\"elementor-widget-wrap\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-0692aed elementor-widget elementor-widget-heading\" data-id=\"0692aed\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Pedido de Ensaio Cl\u00ednico APROVADO<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-66d2400 elementor-widget elementor-widget-text-editor\" data-id=\"66d2400\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-text-editor elementor-clearfix\">\n\t\t\t\t<p>O nosso candidato a f\u00e1rmaco, S072, \u00e9 uma pequena mol\u00e9cula, inspirada numa mol\u00e9cula marinha e otimizada para a sa\u00fade humana, que atua em neur\u00f3nios perif\u00e9ricos hiperativos atrav\u00e9s da modula\u00e7\u00e3o seletiva de canais i\u00f3nicos-chave. Este mecanismo perif\u00e9rico permite uma analgesia potente, sem efeitos secund\u00e1rios no sistema nervoso central, eliminando riscos de adic\u00e7\u00e3o, seda\u00e7\u00e3o ou d\u00e9fice cognitivo.<\/p><p>O candidato a f\u00e1rmaco destina-se a administra\u00e7\u00e3o oral at\u00e9 duas vezes por dia e demonstrou um excelente perfil de seguran\u00e7a nos testes pr\u00e9-cl\u00ednicos GLP, com efic\u00e1cia superior e maior dura\u00e7\u00e3o de efeito em compara\u00e7\u00f5es diretas com os <em>standards of care<\/em> (por exemplo, morfina).<\/p><p>Os estudos farmacocin\u00e9ticos demonstram elevada biodisponibilidade oral em esp\u00e9cies pr\u00e9-cl\u00ednicas, elevada exposi\u00e7\u00e3o plasm\u00e1tica, baixa liga\u00e7\u00e3o a prote\u00ednas e elevada estabilidade hep\u00e1tica em ratos, c\u00e3es e humanos. A farmacologia de seguran\u00e7a indica aus\u00eancia de intera\u00e7\u00f5es CYP significativas, efeitos off-target ou toxicidade comportamental. O composto \u00e9 bem tolerado em doses, com alta margem de seguran\u00e7a. Foram gerados dados robustos de prova de conceito de efic\u00e1cia em seis modelos animais validados de doen\u00e7a, incluindo dor p\u00f3s-operat\u00f3ria, dor osteoartr\u00edtica, neuralgia do trig\u00e9mio, neuropatia perif\u00e9rica induzida por quimioterapia, dor visceral\/IBD e dor monoartr\u00edtica.<\/p><p>Foram submetidas tr\u00eas patentes. Duas foram concedidas nos Estados Unidos, e a terceira entrou em PCT em 2025 e foi publicada em janeiro de 2026.<\/p><p>A estrat\u00e9gia cl\u00ednica para o S072 tem in\u00edcio na indica\u00e7\u00e3o de dor p\u00f3s-cir\u00fargica, sendo posteriormente expandida para indica\u00e7\u00f5es de dor cr\u00f3nica.<\/p>\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-13f6e8e elementor-section-content-space-evenly elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"13f6e8e\" data-element_type=\"section\">\n\t\t\t\t\t\t\t<div class=\"elementor-background-overlay\"><\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-narrow\">\n\t\t\t\t\t\t\t<div class=\"elementor-row\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-3ef560d\" data-id=\"3ef560d\" data-element_type=\"column\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t<div class=\"elementor-column-wrap elementor-element-populated\">\n\t\t\t\t\t<div class=\"elementor-background-overlay\"><\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-widget-wrap\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-770a053 elementor-widget elementor-widget-heading\" data-id=\"770a053\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Produto Pronto para os Ensaios Cl\u00ednicos<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-7c1580c elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"7c1580c\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t\t\t<div class=\"elementor-row\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-850087b\" data-id=\"850087b\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-column-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t<div class=\"elementor-widget-wrap\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-d1ff894 elementor-widget elementor-widget-text-editor\" data-id=\"d1ff894\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-text-editor elementor-clearfix\">\n\t\t\t\t<p>O S072 \u00e9 uma <strong>nova entidade qu\u00edmica (NCE)<\/strong>, simples de sintetizar quimicamente e altamente est\u00e1vel.<\/p><p>O <strong><em>scale-up<\/em> industrial<\/strong> est\u00e1 estabelecido, com qualifica\u00e7\u00f5es certificadas GLP e GMP e elevada pureza.<\/p>\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-a19694c\" data-id=\"a19694c\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-column-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t<div class=\"elementor-widget-wrap\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-ebc0bd6 elementor-widget elementor-widget-text-editor\" data-id=\"ebc0bd6\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-text-editor elementor-clearfix\">\n\t\t\t\t<p>A <strong>Subst\u00e2ncia Ativa<\/strong> para ensaios cl\u00ednicos foi produzida, com estabilidade em curso conforme as normas ICH.<\/p><p>O <strong>Produto Farmac\u00eautico<\/strong> est\u00e1 estabelecido como uma formula\u00e7\u00e3o simples. Os materiais cl\u00ednicos est\u00e3o produzidos e prontos.<\/p>\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-4015f2f elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"4015f2f\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t\t\t<div class=\"elementor-row\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-5e827f6\" data-id=\"5e827f6\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-column-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t<div class=\"elementor-widget-wrap\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-fbdc644 elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"fbdc644\" data-element_type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-39390bf elementor-section-stretched elementor-section-content-space-evenly elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"39390bf\" data-element_type=\"section\" data-settings=\"{&quot;stretch_section&quot;:&quot;section-stretched&quot;}\">\n\t\t\t\t\t\t\t<div class=\"elementor-background-overlay\"><\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-narrow\">\n\t\t\t\t\t\t\t<div class=\"elementor-row\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-3bec182\" data-id=\"3bec182\" data-element_type=\"column\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t<div class=\"elementor-column-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t<div class=\"elementor-widget-wrap\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-c34ed57 elementor-widget elementor-widget-heading\" data-id=\"c34ed57\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">O que \u00e9 a Dor Cr\u00f3nica, qual a sua preval\u00eancia e as suas implica\u00e7\u00f5es para os indiv\u00edduos e a sociedade<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-ec3252c elementor-widget elementor-widget-spacer\" data-id=\"ec3252c\" data-element_type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-95a78c5 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"95a78c5\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t\t\t<div class=\"elementor-row\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-575298c\" data-id=\"575298c\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-column-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t<div class=\"elementor-widget-wrap\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-2acff5d elementor-widget elementor-widget-text-editor\" data-id=\"2acff5d\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-text-editor elementor-clearfix\">\n\t\t\t\t<p>Quando uma pessoa apresenta dor persistente ou recorrente por mais de <a href=\"https:\/\/www.iasp-pain.org\/advocacy\/definitions-of-chronic-pain-syndromes\/\">tr\u00eas<\/a> meses, considera-se que sofre de dor cr\u00f3nica. A dor cr\u00f3nica \u00e9 <a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC6676152\/\">percepcionada<\/a> como uma condi\u00e7\u00e3o, e n\u00e3o apenas como um sintoma associado. V\u00e1rios fatores, incluindo biol\u00f3gicos, psicol\u00f3gicos e sociais, <a href=\"https:\/\/www.iasp-pain.org\/advocacy\/definitions-of-chronic-pain-syndromes\/\">contribuem<\/a> para este tipo de dor.<\/p><p>Estima-se que <a href=\"https:\/\/europeanpainfederation.eu\/imi\/the-future-of-european-pain-research-in-the-european-parliament-march-2023\/?utm_source=chatgpt.com\">100 milh\u00f5es<\/a> de pessoas na Europa e <a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC11609938\/?utm_source=chatgpt.com\">1,6 mil milh\u00f5es<\/a> em todo o mundo sofram de dor cr\u00f3nica, a qual tem sido <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/37053114\/\">associada<\/a> \u00e0 depress\u00e3o, a uma maior taxa de suic\u00eddio, bem como ao uso e abuso de subst\u00e2ncias. Os doentes com dor cr\u00f3nica apresentam uma qualidade de vida limitada, com impacto significativo nas rela\u00e7\u00f5es familiares e sociais, e uma maior probabilidade de abandonar o mercado de trabalho \u2014 s\u00f3 na Europa, estima-se um custo anual de cerca de <a href=\"https:\/\/www.activecitizenship.net\/pressreleases\/319?utm_source=chatgpt.com\">500 mil milh\u00f5es<\/a> de euros, com valores semelhantes nos EUA.<\/p><p>Existem medicamentos dispon\u00edveis para o tratamento da dor cr\u00f3nica, mas muitos s\u00e3o ineficazes para determinados tipos e graus de dor ou, no caso dos opioides, apresentam efeitos secund\u00e1rios significativos, incluindo risco de adi\u00e7\u00e3o e depend\u00eancia. Isto deixa doentes e m\u00e9dicos com op\u00e7\u00f5es terap\u00eauticas limitadas, quando existem, frequentemente \u00e0 custa da seguran\u00e7a ou de um controlo adequado da dor.<\/p>\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-7bd541a elementor-section-content-space-evenly elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"7bd541a\" data-element_type=\"section\">\n\t\t\t\t\t\t\t<div class=\"elementor-background-overlay\"><\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-narrow\">\n\t\t\t\t\t\t\t<div class=\"elementor-row\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-fa553ef\" data-id=\"fa553ef\" data-element_type=\"column\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t<div class=\"elementor-column-wrap elementor-element-populated\">\n\t\t\t\t\t<div class=\"elementor-background-overlay\"><\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-widget-wrap\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-ec284f2 elementor-widget elementor-widget-heading\" data-id=\"ec284f2\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Mais Sobre a Sea4Us<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-6b7617f elementor-widget elementor-widget-text-editor\" data-id=\"6b7617f\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-text-editor elementor-clearfix\">\n\t\t\t\t<p>A Sea4Us foi criada em 2013 como uma spin-off da Universidade NOVA de Lisboa, com a miss\u00e3o de desenvolver novos compostos inspirados no ambiente marinho para responder a necessidades cl\u00ednicas n\u00e3o satisfeitas, em particular aquelas que t\u00eam os canais i\u00f3nicos como alvos terap\u00eauticos. A abordagem \u00fanica da Sea4Us combina biologia marinha e eletrofisiologia para encontrar novas solu\u00e7\u00f5es para um vasto conjunto de condi\u00e7\u00f5es em contexto agudo e cr\u00f3nico. A investiga\u00e7\u00e3o e a utiliza\u00e7\u00e3o da Sea4Us est\u00e3o protegidas, com algumas patentes j\u00e1 concedidas.<\/p><p>A Sea4Us emprega atualmente 20 pessoas e, desde a sua cria\u00e7\u00e3o, angariou 6,8 M\u20ac em investimento privado e subven\u00e7\u00f5es.<\/p>\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-2f90b90 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"2f90b90\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t\t\t<div class=\"elementor-row\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-088f1e7\" data-id=\"088f1e7\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-column-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t<div class=\"elementor-widget-wrap\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-bc44537 elementor-widget elementor-widget-image\" data-id=\"bc44537\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-image\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t<a href=\"https:\/\/sea4us.pt\/sobre-nos\/projects\/sea4market\/\">\n\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"118\" src=\"https:\/\/sea4us.pt\/wp-content\/uploads\/2024\/06\/EU-1024x118.png\" class=\"attachment-large size-large\" alt=\"\" srcset=\"https:\/\/sea4us.pt\/wp-content\/uploads\/2024\/06\/EU-1024x118.png 1024w, https:\/\/sea4us.pt\/wp-content\/uploads\/2024\/06\/EU-300x35.png 300w, https:\/\/sea4us.pt\/wp-content\/uploads\/2024\/06\/EU-768x88.png 768w, https:\/\/sea4us.pt\/wp-content\/uploads\/2024\/06\/EU-1536x177.png 1536w, https:\/\/sea4us.pt\/wp-content\/uploads\/2024\/06\/EU-1040x120.png 1040w, https:\/\/sea4us.pt\/wp-content\/uploads\/2024\/06\/EU.png 1807w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/>\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-c32c0e3 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"c32c0e3\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t\t\t<div class=\"elementor-row\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-33 elementor-top-column elementor-element elementor-element-a82c565\" data-id=\"a82c565\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-column-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t<div class=\"elementor-widget-wrap\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-ef85140 elementor-widget elementor-widget-elementskit-heading\" data-id=\"ef85140\" data-element_type=\"widget\" data-widget_type=\"elementskit-heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<div class=\"ekit-wid-con\" ><div class=\"ekit-heading elementskit-section-title-wraper text_left   ekit_heading_tablet-   ekit_heading_mobile-\"><h2 class=\"ekit-heading--title elementskit-section-title \">\n\t\t\t\t\tVoltar para Not\u00edcias\n\t\t\t\t<\/h2><div class=\"ekit_heading_separetor_wraper ekit_heading_elementskit-border-divider elementskit-style-long\"><div class=\"elementskit-border-divider elementskit-style-long\"><\/div><\/div><\/div><\/div>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-417b2c0 elementor-align-left elementor-widget elementor-widget-button\" data-id=\"417b2c0\" data-element_type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t<a href=\"https:\/\/sea4us.pt\/en\/news-2\/\" class=\"elementor-button-link elementor-button elementor-size-lg elementor-animation-grow\" role=\"button\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t<span class=\"elementor-button-text\">Not\u00edcias<\/span>\n\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-66 elementor-top-column elementor-element elementor-element-c04b991\" data-id=\"c04b991\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-column-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t<div class=\"elementor-widget-wrap\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-6bfffc2 elementor-grid-3 elementor-grid-tablet-2 elementor-grid-mobile-1 elementor-widget elementor-widget-elementor-blog-posts\" data-id=\"6bfffc2\" data-element_type=\"widget\" data-settings=\"{&quot;columns&quot;:&quot;3&quot;,&quot;columns_tablet&quot;:&quot;2&quot;,&quot;columns_mobile&quot;:&quot;1&quot;}\" data-widget_type=\"elementor-blog-posts.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"wpcap-grid\">\n\t\t\t\t\t\t<div class=\"wpcap-grid-container elementor-grid wpcap-grid-desktop-3 wpcap-grid-tablet-2 wpcap-grid-mobile-1 grid-meta-bottom\">\n\n\t\t\t\t\n        <article id=\"post-8271\" class=\"wpcap-post post-8271 post type-post status-publish format-standard hentry category-news\">\n         \n            <div class=\"post-grid-inner\">\n            \t\n            \t\n                <div class=\"post-grid-text-wrap\">\n               \t\t\t\t<h2 class=\"title\">\n\t\t\t<a href=\"https:\/\/sea4us.pt\/pt\/sea4us-featured-at-rtps-sociedade-civil\/\">Sea4Us no programa Sociedade Civil da RTP<\/a>\n\t\t<\/h2>\n\t\t\t                \t                                <\/div>\n\n                \t\t<div class=\"post-grid-meta\">\n\t\t\t\n\t\t\t\t<span class=\"post-date\"><time datetime=\"2026-06-22T16:55:09+00:00\">22\/06\/2026<\/time><\/span>\n\n\t\t\t\t\t\t<\/div>\n\t\t\n            <\/div><!-- .blog-inner -->\n           \n        <\/article>\n\n        \n        <article id=\"post-8122\" class=\"wpcap-post post-8122 post type-post status-publish format-standard hentry category-news\">\n         \n            <div class=\"post-grid-inner\">\n            \t\n            \t\n                <div class=\"post-grid-text-wrap\">\n               \t\t\t\t<h2 class=\"title\">\n\t\t\t<a href=\"https:\/\/sea4us.pt\/pt\/sea4us-featured-in-sabado-portuguese-discoveries-with-the-potential-to-transform-pain-treatment\/\">Sea4Us em destaque na S\u00c1BADO: novas descobertas portuguesas para transformar o tratamento da dor<\/a>\n\t\t<\/h2>\n\t\t\t                \t                                <\/div>\n\n                \t\t<div class=\"post-grid-meta\">\n\t\t\t\n\t\t\t\t<span class=\"post-date\"><time datetime=\"2026-05-18T16:22:14+00:00\">18\/05\/2026<\/time><\/span>\n\n\t\t\t\t\t\t<\/div>\n\t\t\n            <\/div><!-- .blog-inner -->\n           \n        <\/article>\n\n        \n        <article id=\"post-7782\" class=\"wpcap-post post-7782 post type-post status-publish format-standard hentry category-long-post category-news\">\n         \n            <div class=\"post-grid-inner\">\n            \t\n            \t\n                <div class=\"post-grid-text-wrap\">\n               \t\t\t\t<h2 class=\"title\">\n\t\t\t<a href=\"https:\/\/sea4us.pt\/pt\/clinical-trial-application-approval\/\">Submiss\u00e3o a Ensaios Cl\u00ednicos Aprovada!<\/a>\n\t\t<\/h2>\n\t\t\t                \t                                <\/div>\n\n                \t\t<div class=\"post-grid-meta\">\n\t\t\t\n\t\t\t\t<span class=\"post-date\"><time datetime=\"2026-05-01T12:10:52+00:00\">01\/05\/2026<\/time><\/span>\n\n\t\t\t\t\t\t<\/div>\n\t\t\n            <\/div><!-- .blog-inner -->\n           \n        <\/article>\n\n        \n\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Pedido de Autoriza\u00e7\u00e3o de Ensaio Cl\u00ednico APROVADO Previous Next Luz verde para o S072 A aprova\u00e7\u00e3o regulamentar e \u00e9tica do analg\u00e9sico first-in-class da Sea4Us sustenta a efic\u00e1cia promissora do S072, suportada pela sua seguran\u00e7a pr\u00e9-cl\u00ednica. A ativa\u00e7\u00e3o do centro cl\u00ednico teve lugar a 30 de abril de 2026. Sagres, Portugal, 1 de maio de 2026 [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"elementor_header_footer","format":"standard","meta":{"footnotes":""},"categories":[10,38],"tags":[],"class_list":["post-7782","post","type-post","status-publish","format-standard","hentry","category-long-post","category-news"],"_links":{"self":[{"href":"https:\/\/sea4us.pt\/pt\/wp-json\/wp\/v2\/posts\/7782","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/sea4us.pt\/pt\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/sea4us.pt\/pt\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/sea4us.pt\/pt\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/sea4us.pt\/pt\/wp-json\/wp\/v2\/comments?post=7782"}],"version-history":[{"count":84,"href":"https:\/\/sea4us.pt\/pt\/wp-json\/wp\/v2\/posts\/7782\/revisions"}],"predecessor-version":[{"id":8041,"href":"https:\/\/sea4us.pt\/pt\/wp-json\/wp\/v2\/posts\/7782\/revisions\/8041"}],"wp:attachment":[{"href":"https:\/\/sea4us.pt\/pt\/wp-json\/wp\/v2\/media?parent=7782"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/sea4us.pt\/pt\/wp-json\/wp\/v2\/categories?post=7782"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/sea4us.pt\/pt\/wp-json\/wp\/v2\/tags?post=7782"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}